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Journal of Animal Science and Technology
Vol. 56, 57(2014~)
▣ 편집위원장 : 최인호
▣ 편집위원 : 정호영, 최창원, 이철영, 오세종, 김관석,
    이홍구, 송민호, 김은중, 조철훈

논문번호 :
학회지년월 : 201806
접수일자 : 2018-01-31 채택일자 : 2018-06-11
전공분야 : 번식생리및내분비
조 회 수 : 3
Analysis of protein-protein interaction
network based on transcriptome profiling
of ovine granulosa cells identifies candidate
genes in cyclic recruitment of ovarian

Reza Talebi1, Ahmad Ahmadi1* and Fazlollah Afraz2

After pubertal, cohort of small antral follicles enters to gonadotrophin-sensitive development, called recruited follicles.
This study was aimed to identify candidate genes in follicular cyclic recruitment via analysis of protein-protein interaction
(PPI) network. Differentially expressed genes (DEGs) in ovine granulosa cells of small antral follicles between follicular and
luteal phases were accumulated among gene/protein symbols of the Ensembl annotation. Following directed graphs,
PTPN6 and FYN have the highest indegree and outdegree, respectively. Since, these hubs being up-regulated in ovine
granulosa cells of small antral follicles during the follicular phase, it represents an accumulation of blood immune cells
in follicular phase in comparison with luteal phase. By contrast, the up-regulated hubs in the luteal phase including CDK1,
INSRR and TOP2A which stimulated DNA replication and proliferation of granulosa cells, they known as candidate genes
of the cyclic recruitment.
Keywords: Protein–protein interaction network, Biomarkers, Ovarian follicles, Granulosa cells, Cyclic recruitment
논문번호 :
학회지년월 : 201806
접수일자 : 2018-01-26 채택일자 : 2018-06-04
전공분야 : 단위가축영양
조 회 수 : 10
Dietary spray-dried plasma improves
intestinal morphology of mated female
mice under stress condition

Yanhong Liu1†, Jeehwan Choe2†, Sheena Kim2, Byeonghyeon Kim2, Joy M. Campbell3, Javier Polo3,
Joe D. Crenshaw3, James E. Pettigrew4* and Minho Song2*

Background: Stress causes inflammation that impairs intestinal barrier function. Dietary spray-dried plasma (SDP)
has recognized anti-inflammatory effects and improvement of gut barrier function. Therefore, the purpose of this
study was to investigate the effects of dietary SDP on intestinal morphology of mated female mice under stress
Results: Villus height, width, and area of small intestines were low on gestation day (GD) 3 or 4 under stress
conditions, and higher later (Time, P < 0.05). Crypt depth of colon was low on GD 4 and higher later (Time,
P < 0.05). Meanwhile, the SDP treatments improved (P < 0.05) intestinal morphology, indicated by increased
villus height, villus width, villus area, and ratio between villus height and crypt depth of small intestines and
crypt depth of colon, and by decreased crypt depth of small intestines, compared with the control diet. The
SDP treatments also increased (P < 0.05) the number of goblet cells in intestines compared with the
control diet. There were no differences between different levels of SDP.
Conclusion: Dietary SDP improves intestinal morphology of mated female mice under stress condition.
Keywords: Intestinal morphology, Mated female mice, Spray-dried plasma, Stress
논문번호 :
학회지년월 : 201805
접수일자 : 2017-07-25 채택일자 : 2018-05-21
전공분야 : 번식생리및내분비
조 회 수 : 5
Maximum number of total born piglets in a
parity and individual ranges in litter size
expressed as specific characteristics of sows

Gertraude Freyer

Background: The objective of this study was to underline that litter size as a key trait of sows needs new parameters
to be evaluated and to target an individual optimum. Large individual variation in litter size affects both production
and piglet’s survival and health negatively. Therefore, two new traits were suggested and analyzed. Two data sets on
5509 purebred German Landrace sows and 3926 Large White and crossing sows including at least two parental
generations and at least five parities were subjected to variance components analysis.
Results: The new traits for evaluating litter size were derived from the individual numbers of total born piglets (TBP)
per parity: In most cases, sows reach their maximum litter size in their fourth parity. Therefore, data from at least five
parities were included. The first observable maximum and minimum of TBP, and the individual variation expressed by
the range were targeted. Maximum of TBP being an observable trait in pig breeding and management yielded clearly
higher heritability estimates (h2~ 0.3) than those estimates predominantly reported so far. Maximum TBP gets closer to
the genetic capacity for litter size than other litter traits. Minimum of TBP is positively correlated with the range of TBP
(rp = 0.48, rg > 0.6). The correlation between maximum of TBP and its individually reached frequency was negative in
both data sets (rp = &#8722; 0.28 and &#8722; 0.22, respectively). Estimated heritability coefficients for the range of TBP comprised a
span of h2 = 0.06 to 0.10.
Conclusion: An optimum both for maximum and range of total born piglets in selecting sows is a way contributing to
homogenous litters in order to improving the animal-related conditions both for piglets’ welfare and economic
management in pig.
Keywords: Pig, Litter size, Individual maximum, Variation, Heritability, Trait correlation
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